γ射线诱发鼠骨髓干细胞染色体不稳定性传递及时相分析

doi:10.3969/j.issn.1004-616x.1998.02.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (2): 69-071.doi: 10.3969/j.issn.1004-616x.1998.02.002

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THE CELL CYCLE PHASE ANALYSIS IN CHROMOSOMAL INSTABILITY TRANSMISSION INDUCED BY γ RAY IN MOUSE BONE MARROW STEM CELLS

Liu Bingchen , Dong Liankai , J in Hulin , Tian Zhongwei , Mu Chuanjie and Zhou J iwen

Instit ute of Radiation Medicine , Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin 300192

Received:1900-01-01 Revised:1900-01-01 Online:1998-03-30 Published:1998-03-30

Abstract

Abstract: The delayed expression of chromosomal instability could be induced by 137　Cs - γ ray in mouse marrow stem cells in vivo and in vit ro. The result s showed that 1) , After 14 days incubating of irradiated BALB/ C mouse marrow stem cells , the unstable chromosomal aberration still appeared in CFU - A. 2) , The appearance of the unstable chromosomal aberration could persist for above 30 days in irradiated A4 cells. The statistical analysis of dose2effect response was obversed. 3) , The chromosomal instabiliy could be t ransmitted in BALB/ C mice in vivo for up to 30 days.The f requencies for chromosomal aberrations on 30th day is higher than that of 5th、10th and 20th day. The effect s of chromosomal instability t ransmission is unkowns. It is possible that the delay of chromosomal instability expression lead to cells death and cells t ransformation.

Key words: radiation, chromosomal instablity

Liu Bingchen , Dong Liankai , J in Hulin , Tian Zhongwei , Mu Chuanjie and Zhou J iwen. THE CELL CYCLE PHASE ANALYSIS IN CHROMOSOMAL INSTABILITY TRANSMISSION INDUCED BY γ RAY IN MOUSE BONE MARROW STEM CELLS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(2): 69-071.

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THE CELL CYCLE PHASE ANALYSIS IN CHROMOSOMAL INSTABILITY TRANSMISSION INDUCED BY γ RAY IN MOUSE BONE MARROW STEM CELLS

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